Every time i played against the human team under they stairs they lost. It is easy to do hit+run tactics on that base.
However, the pipes is a decent spot. I reccomend that they be in the acutal vent room however, better "defense"
The only real problem with this spot, as with most of the good human spots on this map, is that its far from the orignal location (relitivly). An alien team doing its job on ambushing at S1+S2 (more or less on S2), will make it impossibly hard to reach+build in that spot, as its easy to get to for them if the only thing thats there is a few builders.
To build there, you need either a really stupid alien team, or a really coordinated human team.
I also dont recooment placeing all your spawsn and such there, as it IS cramped. You need another way out if cornered. On second thought, mabey not, seeing as you can just walk aloong the pipes or just drop down below.
Still, it makes an excelent repeater base with an armory+spawn(s)+ and a few turrets. Mabey even the reactor is placed correctly (like in the actuall room.
But like I said the bad part about this is that its hard to build there, and you defiantly dont want to build there at S1 (you will get anahalated). Also, the little pipe room is a very popular alein base spot, and if they get there first, there is going to be problems.